Which type of nicotine replacement therapy produces the fastest absorption?

Nicotine nasal spray is known for providing the fastest absorption of nicotine into the bloodstream among the various nicotine replacement therapies. This rapid absorption is due to the nasal mucosa being highly vascularized, which allows the nicotine to quickly enter the systemic circulation. When the spray is applied inside the nostrils, it bypasses the digestive system and is delivered directly into the bloodstream, leading to swift relief from withdrawal symptoms.

Compared to other forms of nicotine replacement therapy, such as gum, patches, and lozenges, the nasal spray's design specifically facilitates this rapid onset. Nicotine gum and lozenges require time for chewing or dissolving, which means absorption occurs more gradually. The patch, while effective for steady nicotine delivery, releases nicotine slowly over an extended period, leading to a delayed effect in terms of craving alleviation. Therefore, nicotine nasal spray is particularly advantageous for those seeking immediate cessation support due to its quick action.