Which statement is true regarding nicotine nasal spray?

The statement that nicotine nasal spray produces the highest peak of nicotine level is accurate. This attribute is crucial because it reflects the pharmacokinetic profile of the nasal spray, which allows for rapid absorption of nicotine through the nasal mucosa into the bloodstream. This leads to quicker relief of withdrawal symptoms for users and can effectively mimic the rapid onset of nicotine delivery similar to that of smoking.

This characteristic of nicotine nasal spray makes it particularly effective for individuals trying to quit smoking, as it can help manage cravings more quickly compared to other forms of nicotine replacement therapy, such as patches or gum, which have slower absorption rates. The ability to achieve a higher peak level can also be a contributing factor to the risk of dependence when using this method.

The other options either understate the risks of dependence or misrepresent the effects of nasal irritation, lacking the same level of rapid nicotine delivery that this method provides. Understanding these dynamics helps in advising individuals on the most suitable nicotine replacement options tailored to their needs during cessation efforts.