Which of the following should Bupropion SR be avoided in?

Bupropion SR is an antidepressant that is also used to help individuals quit smoking. One key aspect of its pharmacological profile is that it lowers the seizure threshold, which increases the risk of seizures, especially in susceptible individuals. Therefore, it is particularly critical to avoid prescribing Bupropion SR to people with a history of seizure disorders.

Individuals with seizure disorders are at a heightened risk for experiencing adverse effects from Bupropion, as the medication can provoke seizures in this population. This makes it essential for healthcare providers to carefully evaluate a patient's medical history, especially regarding neurological conditions like epilepsy or any prior seizure activity, before initiating treatment with Bupropion SR.

By contrast, while Bupropion can cause side effects like insomnia or dry mouth, these are generally manageable symptoms and do not pose the same level of immediate risk as the potential for seizures associated with a pre-existing seizure disorder. Heart disease is also a consideration for caution due to the potential for increased heart rate, but it does not carry the direct risk of causing seizures. Therefore, the avoidance of Bupropion SR in individuals with a seizure disorder is the most critical guideline in ensuring patient safety.