Which of the following FDA approved pharmacotherapies for tobacco cessation requires a prescription?

Varenicline is a prescription medication that is specifically designed to help individuals quit smoking. It works by targeting nicotine receptors in the brain, which reduces cravings and withdrawal symptoms associated with quitting. By binding to these receptors, Varenicline stimulates them in a way that mimics nicotine but to a lesser extent, thereby helping to alleviate the urge to smoke.

The requirement for a prescription indicates that healthcare providers need to evaluate a patient's health status and consider potential contraindications or interactions with other medications before prescribing Varenicline. This is crucial for ensuring safe and effective use as people may have different medical histories and needs when it comes to smoking cessation.

Other options, such as the nicotine inhaler, bupropion SR, and nicotine gum, are available through different channels, which may include over-the-counter options. Each of these alternatives has its own action mechanism, but Varenicline is uniquely positioned as a prescription-only therapy primarily due to its specific pharmacological profile and the need for medical oversight during its use.